Creatine kinase-mb isoenzyme (CK-MB) can increase as a result of myocardial necrosis.
An
increase in total CK might occur for several reasons, including brain
injury, such as cerebral bleeding; skeletal muscle damage, which can
result from I.M. injections or falls; vigorous exercise; trauma; or surgery, muscular or neuromuscular disease can all be reason for increase in total CK.
